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Introduction The aim of the study was to establish a two-dimensional system based on organic and functional biological age (BA) using a biomarker of organic and functional impairment with aging for precisely assessing roles of natural aging and other risk factors in chronic disease. Material and methods The index of organic mild impairment, which is similar to the frailty index, was determined with imaging parameters as organic BA. The functional BA was calculated with the following formula Functional BA = [systolic - diastolic BP (mm H
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