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The first part of this report details a systemic management and biodistribution of radiolabeled and fluorophore-incorporated ORMOSIL nanoparticles in mice. The 2nd part of this report targets the utilization of ORMOSIL nanoparticles as carriers of plasmid DNA for nonviral gene delivery to your mouse mind. We offer detailed protocols describing preparation and characterization of ORMOSIL nanoparticles, techniques employed for loading the particles with energetic agents (age.g., radioimaging agents, p
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