https://www.selleckchem.com/pr....oducts/thymidine.htm
Based on the largest single-molecule R-loop dataset to date, we show that individual R-loops form non-randomly, defining discrete sets of overlapping molecular clusters that pile-up through larger R-loop zones. R-loops most often map to intronic regions and their individual start and stop positions do not match with intron-exon boundaries, reinforcing the model that they form co-transcriptionally from unspliced transcripts. SMRF-seq further established that R-loop distribution patterns are not simply driven by intrinsic DNA sequence f
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