https://www.selleckchem.com/products/GDC-0449.html
However, RO5263397 did not affect the expression of morphine-induced conditioned place preference in mice or rats. RO5263397 did not affect naltrexone-precipitated jumping behaviour or naltrexone-induced conditioned place aversion in morphine-dependent mice. Furthermore, RO5263397 did not affect the analgesic effects of morphine in an acute nociception model in mice and a chronic pain model in rats. These results indicated that TA receptor activation selectively attenuated the reinforcing, but not withdrawal or antinociceptive effects
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