https://www.selleckchem.com/products/rvx-208.html
Pharmacological analyses showed that phosphorylated/activated p65 downregulates miR-124 via two signaling pathways (1) TAK1/IKKα-IKKβ/IκBα and (2) MAPK/p65. Moreover, ChIP assay demonstrated that p65 directly regulates miR-124 by binding to the NF-κB consensus sequence in its promoter region. Finally, we also confirmed that stable ectopic expression of miR-124 suppresses cell proliferation and survival. CONCLUSION Taken together, our study uncovered a mechanism by which active NF-κB signaling disrupts the function of miR-124 as a tumor
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