https://www.selleckchem.com/pr....oducts/epacadostat-i
Nine variants in 7 patients were novel. The leaky Caucasian, splice site LOPD variant, c.-32-13TG mutation was absent. This first study from India provides an insight into a more severe LOPD phenotype with earlier disease onset at 9.9 years compared to 33.3 years in Caucasian patients, and cardiac involvement more than previously reported. The need for improvement in awareness and diagnosis of LOPD in India is highlighted.The ability of radiotherapy to enhance antigenicity and adjuvanticity of an irradiated tumor has
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