https://www.selleckchem.com/pr....oducts/acalabrutinib
corticosteroids and immunosuppressants more commonly used to manage grades 3-4 irAEs. Rash and endocrine irAEs were independent prognostic factors of RFS and OS in patients treated with adjuvant ipilimumab. Patients experiencing lower grade irAEs derived the most benefit, but we found no significant evidence supporting a negative impact of high dose corticosteroids and immunosuppressants more commonly used to manage grades 3-4 irAEs. Checkpoint inhibitors targeting programmed death receptor-1 (PD-1) have been tested in the neoadju
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