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Substances 1-5 and 7 featured an additional eight-membered O-heterocycle that includes rarely already been reported for ansamycins, plus the Z,Z- and E,E-configurations for Δ2,Δ4 were reported the very first time in geldanamycin analogues. Substance 1 exhibited weak inhibition task towards Hsp90α with an IC50 price of 96 µM, 2-5 revealed mild cytotoxicity against four peoples disease cell lines with IC50 values which range from 13 μM to 86 μM, and 7 had moderate anti-HSV-1 activity with an
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