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However, due to the methodological limitations related to existing studies, no firm conclusion can be drawn. Guidelines and perspectives to advance the field are proposed.Dementia is one of the greatest global challenges for public health; however, the relationship between anticholinergic drugs and dementia remains unclear. The aim of the present study was to perform a systematic review and meta-analysis of the predictive roles of anticholinergic drugs in dementia risk. After pooling fourteen longitudinal and case-control studies with
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