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Production of these catecholamines is under double regulation by both neural components of the sympathetic nervous system and hormonal systems relating to the hypothalamus-pituitary-adrenal axis. Importantly, both neural and hormone arms accept input from the body's main clock, offering increase into the observed rhythmic variants in catecholamine levels in blood and peripheral cells. Oscillations in catecholamine signals possess potential to influence various mobile goals expressing adrenergic receptor
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