https://www.selleckchem.com/pr....oducts/dss-crosslink
Here, the first crystal structure of the TTBK2 kinase domain is described. Furthermore, the crystal structure of human TTBK2 in complex with a small-molecule inhibitor has successfully been determined to elucidate the structural differences in protein conformations between the two TTBK isoforms that could aid in SBDD for the design of inhibitors that selectively target TTBK1 over TTBK2.Twinning is a crystal-growth anomaly in which protein monomers exist in different orientations but are related in a specific way, causing diffrac
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