http://bacterial-receptor.com/....index.php/review-inv
siRNA attained IGFBP‑rP1‑silencing in RF/6A cells without cytotoxicity. IGFBP‑rP1‑silencing notably restored the viability of RF/6A cells in hypoxia and enhanced hypoxia‑induced migration and capillary‑like tube development of RF/6A cells. Additionally, IGFBP‑rP1‑silencing significantly upregulated the phrase of B‑RAF, phosphorylated (p)‑MEK, p‑ERK and VEGF in RF/6A cells under hypoxic circumstances; nonetheless, these upregulations had been inhibited by exogenous IGFBP‑rP1. These data
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