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Comorbidities can impose diagnostic and treatment challenges in clients with multiple sclerosis (MS). Sickle-cell disease (SCD) and MS tend to be both inflammatory diseases featuring immunity dysregulation, as well as the mutual interaction among these diseases deserves research. We provide the actual situation of a 28-year-old lady with SCD whom developed a sickle-cell crisis and acute upper body syndrome during corticosteroid treatment for a first MS attack. We then provide analysis the literary works on
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