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The expression of T-bet and IFN-γ genes in the splenocytes of ATRA, calcitriol and combination- treated mice were significantly reduced compared to vehicle group (p less then 0.05). A significant decrease in T-bet expression was observed in the combination-treated group compared to the ATRA-treated group (p less then 0.05). The expression of GATA3 and IL-4 genes was significantly increased in the ATRA-, calcitriol-, and combination-treated mice when compared with the control group (p less then 0.05). Furthermore, the effect of calcitriol a
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