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In conclusion, our study shows that cystic fibrosis fibroblasts preserve in vitro an activated pro-fibrotic state. This problem may play in vivo a role in the modulation of epithelial and inflammatory cell behavior and lung remodeling. We believe the suggested bioengineered model might provide new insights on epithelial/stromal/inflammatory cells crosstalk in cystic fibrosis, paving just how for novel therapeutic strategies.Thyroid bodily hormones (THs
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