https://marimastatinhibitor.co....m/micro-tomographic-
We've, for the first time, unearthed that Trx1 and telomerase had a dual-target synergistic impact. Centered on that results, we designed a series of 6-dithio-2'-deoxyguanosine analogs (named as YLS00X) and verified whether or not they can inhibit Trx1 and telomerase simultaneously. TrxR1/Trx1 system activity and telomerase expression were substantially inhibited by 6-dithio-2'-deoxyguanosine analogs, specifically YLS004. YLS004 can also trigger ROS accumulation, and induce tumor cellular
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