https://www.selleckchem.com/pr....oducts/cep-18770.htm
Up-and-down procedure (UDP) was recommended to replace traditional acute toxicity methods. However, it was limited due to the long experimental period (20-42 days). To improve UDP, an improved UDP method (iUDP) was developed by shortening observation time between sequence dosages. The aim of this study was to test the reliability of iUDP to provide a reliable method for the acute toxicity measurement of valuable or minor amount compounds. Oral median lethal dose (LD ) of nicotine, sinomenine hydrochloride and berberine hydrochloride w
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