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Correlation analysis revealed that mitochondrial proteins and the synaptic protein were strongly associated with cognitive performance. Conclusion ApoE isoforms influence mitochondrial structure and function, which likely leads to alteration in oxidative stress, synapses, and cognitive function. These mitochondria-related proteins may be a harbinger of cognitive decline in ApoE-ɛ4 carriers and provide novel therapeutic targets for prevention and treatment of AD.Objective To investigate intrarater reliability and concurrent and construct
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