https://www.selleckchem.com/pr....oducts/way-316606.ht
The transmembrane protein 33 (TMEM33) was originally identified as an endoplasmic reticulum (ER) protein that influences the tubular structure of the ER and modulates intracellular calcium homeostasis. However, the role of TMEM33 in antiviral immunity in vertebrates has not been elucidated. In this article, we demonstrate that zebrafish TMEM33 is a negative regulator of virus-triggered interferon (IFN) induction via two mechanisms mitochondrial antiviral signaling protein (MAVS) ubiquitination and a decrease in the kinase activity of
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