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001), longer duration (P0.001) and larger pain area (P0.001) than isotonic saline. There were no significant differences in any pain variable between sterile water and hypertonic saline. The PPT did not change significantly after any substance, except for in women 5minutes after sterile water injection (P0.002). Pain duration was longer in the men for all substances (P0.006), while the pain area was larger in women after injection of hypertonic saline (P0.003). These results indicate that pain evoked by sterile water
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