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05). Both sympathetic and parasympathetic tones were altered in dogs with MVD before clinical signs were observed and prior to the development of cardiomegaly. This is the first HRV study in untreated dogs with MVD. Investigating ANS imbalances preceding subclinical left-sided cardiomegaly in dogs with MVD should be considered in future age-matched, longitudinal studies to determine the potential benefits of early vagal tone augmentation in high-risk canine patients.Sorbitol dehydrogenase (SDH) activity is one of the most sensitive and s
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