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One of the major challenges faced when treating high-risk keratinocyte carcinoma (KC) is the unpredictable subclinical extension. Yaroslavsky et al. (202 evaluated dual-wavelength optical polarization imaging (OPI) for the detection for KC margins before Mohs surgery with promising results. OPI might be useful as a screening tool to limit unnecessary surgery.In the current issue, Haug et al. 2020 report on the prognostic impact of perineural invasion (PNI) and desmoplasia on cutaneous squamous cell carcinoma (CSCC) recurrence and metastasis. They find tha
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