https://www.selleckchem.com/pr....oducts/Camptothecine
More interestingly, we also found that HDRsEf1 could stabilize ZO-1 expression through inhibiting the production of TNF-α induced by LPS. HDRsEf1 could protect the IPEC-J2 cell against LPS induced down-regulation of ZO-1 expression by inhibiting the activation of TLR2/4-mediated JNK-AP-1 and signalling cascade and the production of TNF-α. This study can provide a theoretical basis for probiotics to regulate the expression of intestinal tight junction proteins, and supply technical support for probiotics to prevent and treat animal
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