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028, 95% confidence interval [CI] 0.012 to 0.043), episodic memory (β=0.028, 95% CI 0.010 to 0.047) and working memory (β=0.019, 95% CI 0.005 to 0.033) during the follow-up. In brain pathological data analysis, the association of the highest CR with cognitive function changes remained significant among participants with high Alzheimer's disease pathology or gross infarcts. High CR indicator is associated with preserved global cognitive function, episodic memory, and working memory, even in the presence of brain pathologies. Our findings
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