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Chlorothalonil also induced oxidative stress as indicated by elevated biochemical markers. The highest recorded mortalities were associated with p53 expression. Additional feeding experiments were conducted with fucoidan (8 g/kg diet), following acute (40 μg/L for seven days) and sub-chronic (20 μg/L for six weeks) chlorothalonil application in Nile tilapia. Many of these same biochemical biomarkers of stress, oxidative damage response, and tissue pathology (evidence for hepatic neoplasm) were ameliorated by fucoidan, suggesting a protec
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