https://www.selleckchem.com/ph....armacological_epigen
Acitretin is a member of vitamin A-derived retinoids and its effect on vascular smooth muscle had not been studied yet. The aim of this study is to investigate the effect of acitretin, a retinoid, on vascular smooth muscle contractility. Thoracic aorta preparations obtained from 34 male Sprague-Dawley rats (355 ± 15 g) were studied in isolated organ baths containing Krebs-Henseleit solution. The relaxation responses were obtained with acitretin (10-12‒10-4 M) in endothelium-preserved and endothelium-denuded aorta preparations
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