https://www.selleckchem.com/pr....oducts/selonsertib-g
16; 95% confidence interval [CI] 0.51-0.73), grade≥3 diarrhea (RR 0.36; 95% CI 0.18-0.72), and grade≥2 diarrhea (RR 0.65; 95% CI 0.54-0.78), but not that of grade≤2 diarrhea (RR 1.07; 95% CI 0.95-1.21), was significantly reduced in the probiotics compared to the placebo groups. No significant increase in the incidence of AEs was found in the probiotics group, although four studies reported a variety of AEs. Probiotics prevented chemoradiotherapy-induced diarrhea, particularly high-grade diarrhea. Probiotics rarely cause AEs.
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