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Antiviral-resistant influenza viruses in the clinical environment, especially type B, are reported rarely. A stem cell transplant recipient remained influenza B positive for 2 months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119. © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.Objective Integrase strand transfer inhibitors (INSTI) hav
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