https://lamivudineinhibitor.co....m/a-manuscript-total
Add-back of MAML1 variations in knockout cells identifies residues 151-350 of MAML1 as essential for phrase of either Notch-responsive gene. Fusion for the Notch-binding region of MAML1 to the histone acetyltransferase (HAT) domain of p300 rescues expression of HES4 yet not DTX1, recommending that yet another task of MAML1 becomes necessary for gene induction well away. Collectively, these studies establish the useful need for the MAML1 151-350 area for Notch-dependent transcriptional
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