https://www.selleckchem.com/pr....oducts/cetuximab.htm
002). Both AT depots converted circulating E S to estrone, and estrone to estradiol. Median levels of estrone were five to ten times higher in subcutaneous and visceral AT than in serum (P 0.001) and the estradiol level in visceral AT was 1.3 times higher than in serum (P 0.005). The local estrone concentration in visceral AT correlated positively with mRNA expression of estrone-producing enzyme aromatase (r = 0.65, P = 0.003). Waist circumference correlated positively with increased estradiol production in subcutaneous AT (
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