https://www.selleckchem.com/pr....oducts/gkt137831.htm
In addition to promoting cystoblast divisions and meiotic entry, dazl is required for germline stem cell establishment and fertility. Standard-of-care treatment for metastatic hormone receptor-positive (HR ), HER2-negative (HER2 ) breast cancer includes endocrine therapy (ET) combined with a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i). Optimal treatment after progression on CDK4/6i is unknown. The TRINITI-1 trial investigated ribociclib, a CDK4/6i that has recently demonstrated significant overall survival benefit in two phase III
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