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The population was predominantly middle-age (mean of 58.7 years-old), overweight (median of BMI 26.7 kg/m ) and male subjects (69.7%). Patients with AO showed higher values of SAF (p = 0.04) and 2SC (p = 0.047). No differences were observed for plasma AGEs. SAF and 2SC were significantly associated with the presence of AO after adjusting for age, gender, smoking history, BMI and Mediterranean diet score (p = 0.041 and p = 0.038, respectively). Skin AGEs and 2SC are increased in patients with moderate to severe AO and independently assoc
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