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Thus, compound 1, but not 2, was able to induce apoptosis-like effects in E. histolytica trophozoites by intracellular production of ROS that affected the actin cytoskeleton structuration. In vivo, compound 1 was more active than compound 2 to reduce the development of ALA.We have developed combinatorial techniques for the enumeration of isomers of polysubstituted giant fullerenes through icosahedral C150000 and applied the techniques to chirality of the isomers, NMR spectroscopy, and group theoretical analysis of the vibrational modes
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