https://www.selleckchem.com/pr....oducts/dual-specific
05). Both METTL3 overexpression and IL-1β treatment promoted expression of p65 protein and p-ERK (p less then 0.01). Additionally, increased expression of MMP1 and MMP3, and decreased expression of MMP13, TIMP-1, and TIMP-2 at both mRNA and protein levels were observed in the METTL3 overexpression group when compared with the control group (p less then 0.01). Expression of m6A methylation gene METTL3 was reduced in OA. METTL3 is involved in OA probably by regulating the inflammatory respons
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