https://www.selleckchem.com/pr....oducts/NVP-AUY922.ht
To the opposite, overexpression of TOP2A in Hela cells induced opposite results. In addition, the expression of p-AKT was increased when TOP2A was overexpressed in Hela cells, and p-AKT expression was decreased when TOP2A was silenced in SiHa cells. Moreover, suppression of the PI3K/AKT signaling with LY294002 treatment apparently rescued TOP2A-mediated promotions in cell migration, invasion and EMT in Hela cells. Conclusion This study reveals that TOP2A is abnormally overexpressed in cervical cancer tissues, and TOP2A overexpression
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