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5 mg/m cohort; grade 2 thromboembolic event in the 24 mg/m cohort; and grade 3 peripheral sensorimotor neuropathy, grade 3 elevated aspartate aminotransferase, and grade 3 hypertension in the 32 mg/m cohort. The MTD was 24 mg/m , and average half-life was ~2.5 hours. The area under the curve-dose response relationship was linear. Nineteen subjects were stable after two cycles. The longest treatment lasted 24 cycles. SCB01A-induced neurotoxicity was reversible in vitro. The MTD of SCB01A was 24 mg/m every 21 days; it is safe and tolerabl
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