https://www.selleckchem.com/pr....oducts/CP-690550.htm
Single-channel measurements revealed higher RyR2 open probability at low resting Ca in GRMD cardiomyocytes than in controls. ARM036 prevented those invivo and invitro dysfunctions in GRMD dogs. Myofilament Ca -sensitivity was increased in permeabilized GRMD cardiomyocytes at short sarcomere length. ARM036 had no effect on this parameter. Cross-bridge cycling kinetics were altered in GRMD myocytes and recovered with ARM036 treatment, which coincided with the level of myosin binding protein-C-S glutathionylation. GRMD-dogs exhibit early
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