https://www.selleckchem.com/pr....oducts/pexidartinib-
A synthetic strategy to fused bicyclic piperidines-building blocks for medicinal chemistry-is developed. The key step was an intramolecular [2 + 2]-photocyclization. The photochemical step was performed on a gram scale. Crystallographic analysis of the obtained compounds revealed that they occupy a novel chemical space and can be considered as elongated analogues of 3-substituted piperidines.The recent "US-China trade war" has aroused concern over trade-related environmental impacts. This study built a multiregional computa
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