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Herein, we aim at assessing which dimension, photons or electrons, yields much better biosensor performance. Upon detailing an update in recent achievements to enhance analytical performance, amperometry and chemiluminescence (CL)-based biosensors are right compared employing the same biospecific reagents and analytical formats. Horseradish peroxidase (HRP) and hydrogen peroxide levels were straight measured, while sugar and mouse IgG were detected employing an enzyme paper-based biosensor and an immunosenso
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