https://www.selleckchem.com/pr....oducts/yap-tead-inhi
The cerebrovascular contractile responses to vasoconstrictors were enhanced in HU rats compared to control rats, and IP R protein/mRNA levels were significantly upregulated. The current densities and open probabilities of K and BK decreased and increased, respectively. Treatment with the mitochondrial-targeted antioxidant mitoTEMPO attenuated mitochondrial fission by upregulating MFN1/2 and downregulating DRP1/FIS1. It also decreased IP R expression levels and restored the activities of the K and BK channels. Mit
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