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5 vs 2; p=0.04) and better improvement in HF symptoms (patients with ≥1 NYHA improvement 87.09% vs 67.74%; p=0.04). There were fewer deaths per 100 patient-year (6.45 vs 9.37; p=0.04) and more narrowing of QRS duration (Δ12.56±3.11ms vs Δ7.29±1.87ms; p=0.04) with quadripolar lead use. Lead related complications were significantly more with the use of bipolar lead (74.19% vs 41.94%; p=0.02). Our prospective, non-randomized, single-center observational study reveals that patients receiving CRT with quadripolar leads have a better response to therapy,
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