https://www.selleckchem.com/products/AZD0530.html
FTY720 reduced the secretion of IL-1β, IL-6, and IL-8 from TNF-α-stimulated MH7A cells in a dose-dependent manner. FTY720 also inhibited TNF-α-induced phosphorylation of NF-κBp65 and IκBα, as well as NF-κBp65 nuclear translocation, in a dose- and time-dependent manner. Interestingly, FTY720 blocked PI3K/Akt, the upstream targets of the NF-κB pathway. Our findings demonstrated that oral administration of FTY720 exerted beneficial effects in CIA mice by inhibiting CD4 T lymphocyte recruitment to the affected joints. Our data also indicate
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