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How Does ADHD Medication Work? ADHD is treated by taking stimulants. They regulate the levels of two brain chemicals (neurotransmitters) that convey messages between neurons to improve attention and decrease hyperactivity. However, as much as 20% of people do not respond to the most frequently prescribed stimulants, methylphenidate or amphetamine. This could be due to the body's chemistry or other medications they are taking. What are the symptoms of
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