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Finally, we show that pre-synaptic active zones are preferentially removed from severed axons within hours after injury and that depriving recently injured flies of sleep slows the removal of both active zones and damaged axons. These data support a bidirectional interaction between sleep and synapse pruning after antennal injury locally increasing the need to clear neural debris is associated with increased sleep, which is required for efficient active zone removal after injury. Sleep is universal across species and essential for quality
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