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The bench design and the DAS allowed measuring the outflow of GFs in different spreaders and demonstrated that this parameter was influenced by particle segregation. The segregation of GF1 was higher than that of GF2. The outflow variability at the speed of 1.11 m s-1 was lower, and the spreader with a fluted roller had the highest uniformity and was the most suitable for application with variable rates.Niemann-Pick disease type C is a rare, fatal neurodegenerative disorder characterized by massive intracellular accumulation of cholesterol
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