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An extra option to modify vaccine transfer to lymph nodes and spleen may be the formulation with micron-sized adjuvants that creates a local depot and results in a slow launch of antigen and adjuvant. Ideally, the adjuvant in inclusion promotes the inborn defense mechanisms. The characteristics of this resistant response can be more improved by inclusion of Toll-like receptor ligands, which many VLPs naturally package. Thus, thinking about the 3Ds in v
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