https://www.selleckchem.com/pr....oducts/sch-900776.ht
Simulations show that with the proposed method a coherent pulse of a few microjoules pulse energy and femtosecond duration can be generated with a typical LPA beam.The phase problem is a persistent bottleneck that impedes the structure-determination pipeline and must be solved to obtain atomic resolution crystal structures of macromolecules. Although molecular replacement has become the predominant method of solving the phase problem, many scenarios still exist in which experimental phasing is needed. Here, a proof-of-concept study i
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