https://www.selleckchem.com/pr....oducts/LY2228820.htm
Chronic viral infections disrupt the ability of the humoral immune response to produce neutralising antibody or form effective immune memory, preventing viral clearance and making vaccine design difficult. Multiple components of the B cell response are affected by pathogens that are not cleared from the host. Changes in the microenvironment shift production of B cells to short-lived plasma cells early in the response. Polyclonal B cells are recruited into both the plasma cell and germinal centre compartments, inhibiting the formation
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