https://www.selleckchem.com/pr....oducts/epacadostat-i
The effects of CI on VEGF-induced proangiogenic genesandsignaling pathways were examined in vitro and in vivo. Significant CD31 and VEGF expressions were detected in the synovial tissues of mice with CIA, similar to their expressions observed in human RA patients. However, treatment with CI significantly inhibited paw swelling, decreased the mean articular index and joint pathology scores in these animals through inhibition of VEGF-induced proangiogenicgene expressions andsignaling pathways that regulate angiogenesis. Unl
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