https://gpnainhibitor.com/conc....ussion-education-in-
Right here we assign a pivotal role for Rabgap1 (GAPCenA) in the recycling of endocytosed active β1 integrins to the plasma membrane. The phosphotyrosine-binding (PT domain of Rabgap1 binds into the membrane-proximal NPxY motif when you look at the cytoplasmic domain of β1 integrin subunits on endosomes. Silencing Rabgap1 in mouse fibroblasts leads to the intracellular buildup of active β1 integrins, alters focal adhesion formation, and reduces cell migration and cancer cell intrusi
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